Detection of Sole and Clonal Aneuploidy in Hematologic Malignant Diseases

Manadava V RAO, Nidhi P SHAH, Parth S SHAH, Nirzary H BHATT, Krishna MISTRY, Jeanny DOMINIC, Mudra KANSARA, Samiksha HAKIM, Sandip C SHAH


Numerical  chromosomal  aneuploidy  have  has diagnostic  and  prognostic value  in  detection  of  cancer.  Hence, the study was undertaken in leukemic cases in our diagnostic laboratory. Analysis  of  211  leukemic  blood  samples  from  referral  cases  of  NeubergSupratech  Referral  Laboratory  (NSRL),  Ahmedabad, India, since  2017 to  2019  using  WHO  protocols  for  chromosomal  study. Detection  of  23  cases  were  obtained (23/ 211: 11%)  with  this  condition.  Trisomy  8,  11,  13,  21  and monosomy  7  contributed  to  18  cases  (18/ 23; 78%)  with  5  clonal  anomaly  (5/23; 22%).  Four  clonal  patients  were  +8, +21  and  +21,  XXY  and  -7  with  XY  cells.  Another  karyotype  with  48,XY,+8,+19/  47,XY,+8  was  detected  which  seems  to  be  a  new cytogenetic anomaly in  the  literature  causing  haematologic  neoplasms  in this cohort.

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